Factorial Design Approach as a Tool of Optimization Methodology

Extraction of Terminaliaarjuna bark was done by using maceration technique whereas quantitative estimation of arjunolic acid was performed by using titration method extract. From the preliminary phytochemical test it was found that the alkalis, cardiac glycoside, tannins, tri terpenoids and saponins present in extract. In order to predict the optimum performance of prepared transdermal patch of Terminaliaarjuna we adopted a 32 factorial design approach. Amount of HPMC K100 and Eudragit RL100 were selected as independent variables and percent drug release as dependent variable. Various parameter studied include thickness, flatness, moisture uptake, moisture content, tensile strength, drug content and drug diffusion.

Extraction of Terminaliaarjuna bark was done by using maceration technique whereas quantitative estimation of arjunolic acid was performed by using